Dr. Steven Narod's research team has established several cancer genetic repositories and accompanying databases:
The Henrietta Banting Breast Centre
The Henrietta Banting Breast Centre (HBBC) database contains information about new breast cancer cases seen at Women's College Hospital. To date, clinical and risk factors have been recorded for over 2,500 women. The registry is now the largest repository of records available tracing information about women with breast cancer.
Registry of BRCA carriers
This is an international registry of women above the age of 25 years old who have been found to have a deleterious mutation in either the BRCA1 or BRCA2 gene. It is housed at the Familial Breast Cancer Research Unit in Toronto. Information on medical histories and risk factors is collected in the form of questionnaires and family pedigrees. There are currently over 10,000 study subjects enrolled from 65 centers in 11 countries in Canada, USA, and Europe, and Asia. This registry is the result of the multicenter study entitled: Risk Factor Analysis of Hereditary Breast and Ovarian Cancer.
Familial Ovarian Tumour Study
This collaborative study includes women that were diagnosed with ovarian cancer in Ontario between 1995 and 1999. To date, we have collected a DNA sample, pedigree and lifestyle questionnaire on more than 1800 women. This is the largest database of its type.
Dr. Narod's DNA bank at Women's College Hospital now holds samples from over 25,000 study subjects, of whom approximately 20,000 are cancer patients and 5,000 are controls. Most of the major cancer sites are represented. Family trees are available for the majority of the patients and controls.
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