Women's College Research Institute

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Join our Study on Preventive Ovarian Surgery and Bone and Heart Health!

Study title: The Effect of Prophylactic Salpingo-oophorectomy on Markers of Health in women who carry a BRCA mutation

Purpose: Women who carry a BRCA mutation may choose to remove their ovaries and fallopian tubes to reduce their risk of developing breast and ovarian cancer. Women who undergo this surgery are at risk of significant health changes, especially if they are premenopausal before surgery. The purpose of this study is to document the impact this surgery has on cardiovascular health, bone density and quality of life including menopausal symptoms and sexual health. In order to evaluate these health changes, we are collecting information from BRCA mutation carriers who are removing their ovaries and fallopian tubes. We are also testing a control population, consisting of women who are negative for a family BRCA mutation, to compare the health changes. The information gained from this study will provide us with more knowledge about how to better care for women with a hereditary predisposition to breast, ovarian and fallopian tube cancer.

Who can participate?
Case group:

  • You have not gone through menopause yet (premenopausal)
  • You are a BRCA1 or BRCA2 mutation carrier
  • You are deciding to proceed with prophylactic salpingo-oophorectomy (removal of ovaries and fallopian tubes)
  • You may or may not have a history of breast cancer

More information on case group.


Control group:

  • You do not have a BRCA mutation but someone else in your family does
  • You have not gone through menopause yet (premenopausal)
  • You have not been diagnosed with any type of cancer
  • You have both ovaries intact and you are not pregnant

More information on control group.


What will participation involve? You will attend two study visits, each approximately 2.5 hours long and consisting of the same tests each visit. You will undergo 4 measurements of cardiovascular health: blood pressure, blood draw (fasting glucose, HDL/LDL cholesterol, DNA banking, and vitamin D), an ultrasound on your arm to measure artery flow, and arterial stiffness. To measure bone health, a bone mineral density x-ray will be completed. To measure quality of life, a series of questionnaires will be completed asking questions about general health history, calcium dietary intake, menopausal symptoms, sexual functioning, general health, psychological functioning, and worry about cancer.

For more information about this study, or to sign up to participate, please contact the Research Coordinator at 416-351-3800 ext 2920 or rachel.walker@uhnresearch.ca

This study is voluntary and you may withdraw at any time.

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For More Information

Rachel Walker
Research Coordinator
Familial Breast Cancer Research Unit
Women's College Research Institute
76 Grenville Street, room 6411, Toronto, ON M5S 1B1

Phone: 416-351-3800 ext 2920

Email: rachel.walker@uhnresearch.ca

Current Studies

Risk Factor Analysis of Hereditary Breast and Ovarian Cancer

A Study of Familial Breast Cancer in BRCA-Negative Families

A Study of Familial Cancer in Jewish Women - Follow-up

Cognition in BRCA1 and BRCA2 Mutation Carriers

  • Fully affiliated with:
  • University of Toronto

  • A member of:
  • Council of Academic Hospitals of Ontario (CAHO)